2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-115501
    (E)-FOBISIN101
    (E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research.
    (E)-FOBISIN101
  • HY-P991312
    CM-338
    		Inhibitor
    CM-338 is a human monoclonal antibody (mAb) targeting MASP2. CM-338 can be used in IgA nephropathy research.
    CM-338
  • HY-19303B
    CRA-2059 TFA
    		Inhibitor 99.88%
    CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ).
    CRA-2059 TFA
  • HY-E70203
    Recombinant aprotinin
    		Inhibitor
    Recombinant aprotinin is a serine protease inhibitor. Recombinant aprotinin can inhibit trypsin and related proteolytic enzymes.
    Recombinant aprotinin
  • HY-P3026
    Bowman-birk inhibitor
    The Bowman-Birk inhibitor, a highly cross-linked protein featuring seven disulfide bridges, possesses spatially distinct domains specifically designed for the inhibition of both trypsin and chymotrypsin, showcasing its significant role as a plant protease inhibitor with anticarcinogenic properties.
    Bowman-birk inhibitor
  • HY-134858
    GSK716
    		Inhibitor 99.77%
    GSK716 (A1AT modulator 1) is an orally active Z α1-antitrypsin (Z-A1AT) inhibitor with a pIC50 of 8.3. GSK716 binds a cryptic Z α1-antitrypsin pocket, stabilizes monomeric folding intermediates, blocks polymerization, and increases monomer secretion. GSK716 acts on select sensitive α1-antitrypsin variants but fails to affect resistant variants. GSK716 can be used for the research of α1-antitrypsin deficiency and α1-antitrypsin deficiency-associated liver disease.
    GSK716
  • HY-P5378A
    Ac-KQKLR-AMC TFA
    Ac-KQKLR-AMC TFA is a substrate peptide of Cathepsin S fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). Ac-KQKLR-AMC TFA can be used to measure Cathepsin S activity).
    Ac-KQKLR-AMC TFA
  • HY-105999
    APC 366
    		Inhibitor 99.81%
    APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma.
    APC 366
  • HY-P990952
    Zaltenibart
    		Inhibitor 99%
    Zaltenibart (OMS906) is an IgG4 humanized monoclonal antibody and MASP-3 inhibitor. By inhibiting MASP-3, Zaltenibart achieves upstream inhibition of the alternative complement pathway. MASP-3 is an upstream activator of Factor D (Factor D), a key enzyme in the alternative complement pathway. Zaltenibart prevents both intravascular hemolysis and extravascular hemolysis. Zaltenibart is applicable to research related to paroxysmal nocturnal hemoglobinuria.
    Zaltenibart
  • HY-P0206A
    Bradykinin acetate
    		Inhibitor 99.58%
    Bradykinin acetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin acetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain.
    Bradykinin acetate
  • HY-124762
    TNIK-IN-1
    		Inhibitor 99.25%
    TNIK-IN-1 (Compound 1) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 65 nM, that has antitumor activity.
    TNIK-IN-1
  • HY-147404A
    Tilpisertib fosmecarbil TFA
    		Inhibitor 98.05%
    Tilpisertib fosmecarbil TFA (GS 5290 TFA) is a potent serine/threonine kinase inhibitor. Tilpisertib fosmecarbil TFA has anti-inflammatory activity.
    Tilpisertib fosmecarbil TFA
  • HY-E70127
    Serratiopeptidase
    Serratiopeptidase (Brasan; Dasen) is an orally active zinc-containing metalloprotease belonging to the serralysin family. Serratiopeptidase reduces the release of inflammatory mediators such as prostaglandins, thromboxanes and interleukins by inhibiting COX, thereby relieving pain, swelling and redness. Serratiopeptidase exhibits antibiofilm, mucolytic and wound-healing activities. As a serine protease, Serratiopeptidase has the ability to dissolve blood clots, fibrin and atherosclerotic plaques. Serratiopeptidase degrades amyloid fibrils and has potential anti-Alzheimer's effects. Serratiopeptidase shows cytotoxicity against colon cancer cells.
    Serratiopeptidase
  • HY-P2990
    Enteropeptidase
    Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals.
    Enteropeptidase
  • HY-E70392
    Recombinant Trypsin
    Recombinant Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine.
    Recombinant Trypsin
  • HY-W749874
    Qingdainone
    		Inhibitor
    Qingdainone is a quinazoline alkaloid and also a TMPRSS2 inhibitor. Qingdainone can be isolated from Strobilanthes cusia. Qingdainone exhibits anti-tumor and anti-inflammatory activities. Qingdainone can be used in studies related to chronic myeloid leukemia.
    Qingdainone
  • HY-P0133A
    (Arg)9 TFA
    		Inhibitor 99.57%
    (Arg)9 (Nona-L-arginine) TFA is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 TFA has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
    (Arg)9 TFA
  • HY-19727A
    FOY 251
    		Inhibitor 99.31%
    FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay.
    FOY 251
  • HY-P3798
    Eglin c (41-49)
    		98.78%
    Eglin c (41-49) is a peptide fragment related to eglin c. Eglin c (41-49) shows inhibitory effects to cathepsin G and α-chymotrypsin with Ki values of 42 and 20 μM, respectively.
    Eglin c (41-49)
  • HY-148239
    TP-030-2
    		Inhibitor 98.17%
    TP-030-2, a chemical probe, is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM).
    TP-030-2
Cat. No. 상품명 / Synonyms Application Reactivity